Journal of Bone and Mineral Research, 07/16/2013 Review Article
Eriksson AL et al. – Epidemiological studies have shown low grade inflammation measured by high sensitivity C–reactive protein (hs–CRP) to be associated with fracture risk in women. However, it is still unclear whether hs–CRP is associated with fracture risk also in men. The authors demonstrate, using a large prospective population–based study, that elderly men with high hs–CRP have increased risk of fractures, and that these fractures are mainly vertebral. The association between hs–CRP and fractures was independent of BMD.