Extracellular 14-3-3 protein is a novel biomarker associated with joint damage in rheumatoid arthritis

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‎14.3.3 eta Protein questdiagnostics.com
Extracellular 14-3-3 protein is a novel biomarker associated with joint damage in rheumatoid arthritis and in psoriatic arthritis. Serum 14-3-3 concentration is significantly higher in rheumatoid arthritis patients with active...
Methodology
Enzyme Linked Immunosorbent Assay (ELISA)

Reference Range(s)
<0.2 ng/mL

Clinical Significance
Extracellular 14-3-3 η protein is a novel biomarker associated with joint damage in rheumatoid arthritis and in psoriatic arthritis. Serum 14-3-3 η concentration is significantly higher in rheumatoid arthritis patients with active joint disease and in patients with psoriatic arthritis than in patients with inactive rheumatoid arthritis, psoriasis without arthritis, other autoimmune disorders or healthy controls. The measurement of 14-3-3 η complements RF and CCP antibody tests and improves diagnostic, prognostic and therapy monitoring applications. Additionally, 14-3-3 η has been shown to be a marker of early RA that may contribute to pathological processes of the disease through induction of metalloproteinases and other inflammatory mediators of joint erosion.
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