Los efectos de la pregabalina oral en el dolor postoperatorio de extremidades inferiores en cirugía ortopédica: Estudio doble ciego, placebo controlado.
Los efectos de la pregabalina oral en el dolor postoperatorio de extremidades inferiores en cirugía ortopédica: Estudio doble ciego, placebo controlado.
The effects of oral pregabalin on post-operative pain of lower limb orthopedic surgery: A double-blind, placebo-controlled trial
Akhavanakbari G, Entezariasl M, Isazadehfar K, Mirzarahimi T.
Perspect Clin Res [serial online] 2013 [cited 2013 Jul 22];4:165-8.
Abstract
Background: Post-operative pain is one of the problems, wherein lack of control on it has many side-effects such as tachycardia, hypertension, myocardial ischemia, decreased alveolar ventilation, and poor wound healing. Aims: In this study, we evaluated the pre-operative administration of pregabalin sufficiency and security in relieving post-operative pain after lower limb orthopedic surgery and reducing the need for opioids and their possible side-effects. Materials and Methods: This study is a randomized, double-blind clinical trial. It was performed on 60 patients under lower limb surgery by spinal anesthesia. Patients were randomly allocated to two groups, one group has received a 150 mg pregabalin capsule 2 h before surgery and the other group has received placebo as a control. In both groups at 2, 6, 12, and 24 h after surgery, the patients were evaluated and the pain score, the score of sedation, incidence of nausea and vomiting was recorded in the checklists. Then, the data were analyzed by SPSS v16. Results: Visual analog pain scores at all hours in pregabalin group significantly reduced compared to the placebo group ( P < 0.0001). Also, in the pregabalin group nausea and vomiting scores at all hours, sedation levels at 2 h and 6 h post-operatively, and pethidine consumption in all hours have significantly been reduced. Conclusion: A single pre-operative oral dose of pregabalin 150 mg is an effective method for reducing post-operative pain and pethidine consumption in patients undergoing orthopedic surgery.
Keywords: Pethidine, post-operative pain, pregabalin, visual analogue scale
http://www.picronline.org/text.asp?2013/4/3/165/115376
Atentamente
Anestesiología y Medicina del Dolor
www.anestesia-dolor.org
- See more at: http://paveca3.blogspot.mx/#sthash.DNosqKO5.dpuf
Los efectos de la pregabalina oral en el dolor postoperatorio de extremidades inferiores en cirugía ortopédica: Estudio doble ciego, placebo controlado.
The effects of oral pregabalin on post-operative pain of lower limb orthopedic surgery: A double-blind, placebo-controlled trial
Akhavanakbari G, Entezariasl M, Isazadehfar K, Mirzarahimi T.
Perspect Clin Res [serial online] 2013 [cited 2013 Jul 22];4:165-8.
Abstract
Background: Post-operative pain is one of the problems, wherein lack of control on it has many side-effects such as tachycardia, hypertension, myocardial ischemia, decreased alveolar ventilation, and poor wound healing. Aims: In this study, we evaluated the pre-operative administration of pregabalin sufficiency and security in relieving post-operative pain after lower limb orthopedic surgery and reducing the need for opioids and their possible side-effects. Materials and Methods: This study is a randomized, double-blind clinical trial. It was performed on 60 patients under lower limb surgery by spinal anesthesia. Patients were randomly allocated to two groups, one group has received a 150 mg pregabalin capsule 2 h before surgery and the other group has received placebo as a control. In both groups at 2, 6, 12, and 24 h after surgery, the patients were evaluated and the pain score, the score of sedation, incidence of nausea and vomiting was recorded in the checklists. Then, the data were analyzed by SPSS v16. Results: Visual analog pain scores at all hours in pregabalin group significantly reduced compared to the placebo group ( P < 0.0001). Also, in the pregabalin group nausea and vomiting scores at all hours, sedation levels at 2 h and 6 h post-operatively, and pethidine consumption in all hours have significantly been reduced. Conclusion: A single pre-operative oral dose of pregabalin 150 mg is an effective method for reducing post-operative pain and pethidine consumption in patients undergoing orthopedic surgery.
Keywords: Pethidine, post-operative pain, pregabalin, visual analogue scale
http://www.picronline.org/text.asp?2013/4/3/165/115376
Atentamente
Anestesiología y Medicina del Dolor
www.anestesia-dolor.org
- See more at: http://paveca3.blogspot.mx/#sthash.DNosqKO5.dpuf
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