Exercise could reduce bone tumor growth

The study, which involved both animal and in vitro models, showed that causing bone to bear moderate, repeated weight – akin to an exercise regimen – led to inhibited growth of bone tumors composed of metastasized breast cancer cells. The researchers think that such mechanical stimulation might reduce the expression of genes that interfere with normal, healthy bone functioning. Published online May 3 by the Journal of Bone and Mineral Research, the study was led by first author and postdoctoral researcher Maureen Lynch and senior author Claudia Fischbach-Teschl, associate professor of biomedical engineering.
"Specifically, physically mediated mechanisms in bone might be contributing to bone loss in cancer patients," she said. "So harnessing those things better is what could really help patients."
The paper is titled "In Vivo Tibial Compression Decreases Osteolysis and Tumor Formation in Human Metastatic Breast Cancer Model."
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onlinelibrary.wile… 6/references Journal reference: Journal of Bone and Mineral Research Provided by Cornell University

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